Curing "incurable" cancer.
نویسنده
چکیده
Cancer cells are preferentially killed by anticancer agents because key signals for growth and cell division are "always on" as opposed to the alternative "on" and "off" signaling of normal cells. Too much of today's anticancer drug discovery effort may go toward reversing genetically promoted "always on" signals. More effective anticancer drug targets may be found through use of RNAi technologies that pinpoint the key gene regulatory and metabolic weakness of the "always on" cancer cells.
منابع مشابه
Survey of companions of cancer patients about the need and how to express getting incurable cancer
Introduction: Expressing bad news in medicine is one of the most important measures taken by medical staff that should be given to patients in special circumstances that it is necessary to examine the views of companions and patients in this regard. Therefore, the aim of this study was to investigate the necessity and manner of expressing bad news (incurable cancer) from the perspective of canc...
متن کاملPalliative care consultation services in hospitals in the Netherlands: the design of the COMPASS study
BACKGROUND Patients with an advanced incurable disease are often hospitalised for some time during the last phase of life. Care in hospitals is generally focussed at curing disease and prolonging life and may therefore not in all cases adequately address the needs of such patients. We present the COMPASS study, a study on the effects and costs of consultation teams for palliative care in hospit...
متن کاملAnalysis of surgery for incurable gastric cancer
BACKGROUND It is important to evaluate the curability of and avoid unnecessary exploratory surgery for gastric cancer preoperatively. However, no related research has been reported until now. The aim of this study was to evaluate the factors influencing surgery for incurable gastric cancer. METHODS 310 cases of T3-4 gastric cancer patients were analyzed retrospectively, including 141 cases wi...
متن کاملAn Invitation from the Editors of Cardio-Oncology
Advances in cancer treatments have brought hope to patients with these diseases once thought to be incurable. However, these same treatments can inadvertently harm healthy cells and affect systems unrelated to the cancer, especially the cardiovascular system [1]. A precise definition of cardiotoxicity is still lacking [2]. However, an overwhelming body of evidence has established that patients ...
متن کاملRecent advances in cancer stem/progenitor cell research: therapeutic implications for overcoming resistance to the most aggressive cancers
Overcoming intrinsic and acquired resistance of cancer stem/progenitor cells to current clinical treatments represents a major challenge in treating and curing the most aggressive and metastatic cancers. This review summarizes recent advances in our understanding of the cellular origin and molecular mechanisms at the basis of cancer initiation and progression as well as the heterogeneity of can...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Cancer discovery
دوره 1 6 شماره
صفحات -
تاریخ انتشار 2011